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This meta-analysis induced 12 studies. The conclusion is as follows:
pooled data show that the use of long-acting β-agonists, with and without concomitant inhaled corticosteroids, was associated with a significant increase in the risk of asthma-related intubations and deaths. The magnitude of risk was, in fact, higher for trials with controlled concomitant corticosteroid use (OR 8.2) than for trials with no corticosteroid use at all (OR 2.2)
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Long-acting Beta-Agonists with and without Inhaled Corticosteroids and Catastrophic Asthma Events
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