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Regarding the study, 58 participants were randomized to either receive vitamin B12 1000ug sub-lingual a day or a placebo. A significant number in the treatment group reached 'no aphthous ulcer status' (74.1% vs. 32%; P<0.01)
Effectiveness of Vitamin B12 in Treating Recurrent Aphthous Stomatitis: A Randomized, Double-Blind, Placebo-Controlled Trial -- Volkov et al. 22 (1): 9 -- The Journal of the American Board of Family Medicine
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